Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70

[Image: see text] Heat shock protein 70 (Hsp70) is an important emerging cancer target whose inhibition may affect multiple cancer-associated signaling pathways and, moreover, result in significant cancer cell apoptosis. Despite considerable interest from both academia and pharmaceutical companies i...

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Detalhes bibliográficos
Main Authors: Kang, Yanlong, Taldone, Tony, Patel, Hardik J., Patel, Pallav D., Rodina, Anna, Gozman, Alexander, Maharaj, Ronnie, Clement, Cristina C., Patel, Maulik R., Brodsky, Jeffrey L., Young, Jason C., Chiosis, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983365/
https://ncbi.nlm.nih.gov/pubmed/24548207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401551n
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