Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

Hsp70s are important cancer chaperones that act upstream of Hsp90 and exhibit independent anti-apoptotic activities. To develop chemical tools for the study of human Hsp70, we developed a homology model that unveils a previously unknown allosteric site located in the nucleotide binding domain of Hsp...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Rodina, Anna, Patel, Pallav D., Kang, Yanlong, Patel, Yogita, Baaklini, Imad, Wong, Michael J.H., Taldone, Tony, Yan, Pengrong, Yang, Chenghua, Maharaj, Ronnie, Gozman, Alexander, Patel, Maulik R., Patel, Hardik J., Chirico, William, Erdjument-Bromage, Hediye, Talele, Tanaji T., Young, Jason C., Chiosis, Gabriela
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985611/
https://ncbi.nlm.nih.gov/pubmed/24239008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.10.008
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items