FLIP(L): the pseudo‐caspase

door Smyth, Peter, Sessler, Tamas, Scott, Christopher J., Longley, Daniel B.
Gepubliceerd in FEBS J (2020)

Therapeutics Targeting the Core Apoptotic Machinery

door Hamilton, Claudia, Fox, Jennifer P., Longley, Daniel B., Higgins, Catherine A.
Gepubliceerd in Cancers (Basel) (2021)

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8

door Chacko, Alex D, Liberante, Fabio, Paul, Ian, Longley, Daniel B, Fennell, Dean A
Gepubliceerd in 2010

Epithelial‐to‐mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition

door McCorry, Amy MB, Loughrey, Maurice B, Longley, Daniel B, Lawler, Mark, Dunne, Philip D
Gepubliceerd in J Pathol (2018)

Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer

door Kyula, Joan N., Van Schaeybroeck, Sandra, Doherty, Joanne, Fenning, Catherine S., Longley, Daniel B., Johnston, Patrick G.
Gepubliceerd in 2010

Constitutive and Treatment-Induced CXCL8-Signalling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer

door Wilson, Catherine, Maxwell, Pamela J., Longley, Daniel B., Wilson, Richard H., Johnston, Patrick G., Waugh, David J. J.
Gepubliceerd in 2012

Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL

door Van Schaeybroeck, Sandra, Kelly, Donal M., Kyula, Joan, Stokesberry, Susan, Fennell, Dean A., Johnston, Patrick G., Longley, Daniel B.
Gepubliceerd in 2008

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform

door Matveeva, Anna, Fichtner, Michael, McAllister, Katherine, McCann, Christopher, Sturrock, Marc, Longley, Daniel B., Prehn, Jochen H. M.
Gepubliceerd in PLoS Comput Biol (2019)

Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17

door Van Schaeybroeck, Sandra, Kyula, Joan N., Fenton, Audrey, Fenning, Catherine S., Sasazuki, Takehiko, Shirasawa, Senji, Longley, Daniel B., Johnston, Patrick G.
Gepubliceerd in 2010

Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

door Stevenson, Leanne, Allen, Wendy L., Proutski, Irina, Stewart, Gail, Johnston, Louise, McCloskey, Karen, Wilson, Peter M., Longley, Daniel B., Johnston, Patrick G.
Gepubliceerd in 2011

The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

door Allen, Wendy L, Jithesh, Puthen V, Oliver, Gavin R, Proutski, Irina, Longley, Daniel B, Lenz, Heinz-Josef, Proutski, Vitali, Harkin, Paul, Johnston, Patrick G
Gepubliceerd in 2010

HDAC inhibition overcomes acute resistance to MEK inhibition in BRAF mutant colorectal cancer by down-regulation of c-FLIP(L)

door Carson, Robbie, Celtikci, Basak, Fenning, Cathy, Javadi, Arman, Crawford, Nyree, Carbonell, Lucia Perez, Lawler, Mark, Longley, Daniel B., Johnston, Patrick G., Van Schaeybroeck, Sandra
Gepubliceerd in Clin Cancer Res (2015)

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

door Crawford, Nyree, Salvucci, Manuela, Hellwig, Christian T, Lincoln, Frank A, Mooney, Ruth E, O’Connor, Carla L, Prehn, Jochen HM, Longley, Daniel B, Rehm, Markus
Gepubliceerd in Cell Death Differ (2018)

ELEVATION OF C-FLIP IN CASTRATE-RESISTANT PROSTATE CANCER ANTAGONIZES THERAPEUTIC RESPONSE TO ANDROGEN-RECEPTOR TARGETED THERAPY

door McCourt, Clare, Maxwell, Pamela, Mazzucchelli, Roberta, Montironi, Rodolfo, Scarpelli, Marina, Salto-Tellez, Manuel, O’Sullivan, Joe M., Longley, Daniel B., Waugh, David J.J.
Gepubliceerd in 2012

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

door Barbone, Dario, Cheung, Priscilla, Battula, Sailaja, Busacca, Sara, Gray, Steven G., Longley, Daniel B., Bueno, Raphael, Sugarbaker, David J., Fennell, Dean A., Broaddus, V. Courtney
Gepubliceerd in 2012

Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer

door Stevenson, Leanne, Allen, Wendy L, Turkington, Richard, Jithesh, Puthen V, Proutski, Irina, Stewart, Gail, Lenz, Heinz-Josef, Schaeybroeck, Sandra Van, Longley, Daniel B, Johnston, Patrick G
Gepubliceerd in 2012

Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and mutant colorectal cancer cells

door Allen, Wendy L., Turkington, Richard C., Stevenson, Leanne, Carson, Gail, Coyle, Vicky M., Hector, Suzanne, Dunne, Philip, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Gepubliceerd in 2012

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

door Schmid, Daniela, Fay, Francois, Small, Donna M, Jaworski, Jakub, Riley, Joel S, Tegazzini, Diana, Fenning, Cathy, Jones, David S, Johnston, Patrick G, Longley, Daniel B, Scott, Christopher J
Gepubliceerd in Mol Ther (2014)

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer

door Dunne, Philip D., O'Reilly, Paul G., Coleman, Helen G., Gray, Ronan T., Longley, Daniel B., Johnston, Patrick G., Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.
Gepubliceerd in Oncotarget (2016)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

door Cogo, Francesco, Poreba, Marcin, Rut, Wioletta, Groborz, Katarzyna, Smyth, Peter, Johnston, Michael C., Williams, Richard, Longley, Daniel B., Burden, Roberta E., Salvesen, Guy S., Drag, Marcin, Scott, Christopher J.
Gepubliceerd in Nanoscale (2019)