FLIP(L): the pseudo‐caspase

von Smyth, Peter, Sessler, Tamas, Scott, Christopher J., Longley, Daniel B.
Veröffentlicht in FEBS J (2020)

Therapeutics Targeting the Core Apoptotic Machinery

von Hamilton, Claudia, Fox, Jennifer P., Longley, Daniel B., Higgins, Catherine A.
Veröffentlicht in Cancers (Basel) (2021)

Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8

von Chacko, Alex D, Liberante, Fabio, Paul, Ian, Longley, Daniel B, Fennell, Dean A
Veröffentlicht 2010

Epithelial‐to‐mesenchymal transition signature assessment in colorectal cancer quantifies tumour stromal content rather than true transition

von McCorry, Amy MB, Loughrey, Maurice B, Longley, Daniel B, Lawler, Mark, Dunne, Philip D
Veröffentlicht in J Pathol (2018)

Chemotherapy-induced activation of ADAM-17: a novel mechanism of drug resistance in colorectal cancer

von Kyula, Joan N., Van Schaeybroeck, Sandra, Doherty, Joanne, Fenning, Catherine S., Longley, Daniel B., Johnston, Patrick G.
Veröffentlicht 2010

Constitutive and Treatment-Induced CXCL8-Signalling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer

von Wilson, Catherine, Maxwell, Pamela J., Longley, Daniel B., Wilson, Richard H., Johnston, Patrick G., Waugh, David J. J.
Veröffentlicht 2012

Src and ADAM-17-Mediated Shedding of Transforming Growth Factor-α Is a Mechanism of Acute Resistance to TRAIL

von Van Schaeybroeck, Sandra, Kelly, Donal M., Kyula, Joan, Stokesberry, Susan, Fennell, Dean A., Johnston, Patrick G., Longley, Daniel B.
Veröffentlicht 2008

Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform

von Matveeva, Anna, Fichtner, Michael, McAllister, Katherine, McCann, Christopher, Sturrock, Marc, Longley, Daniel B., Prehn, Jochen H. M.
Veröffentlicht in PLoS Comput Biol (2019)

Oncogenic Kras promotes chemotherapy-induced growth factor shedding via ADAM17

von Van Schaeybroeck, Sandra, Kyula, Joan N., Fenton, Audrey, Fenning, Catherine S., Sasazuki, Takehiko, Shirasawa, Senji, Longley, Daniel B., Johnston, Patrick G.
Veröffentlicht 2010

Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

von Stevenson, Leanne, Allen, Wendy L., Proutski, Irina, Stewart, Gail, Johnston, Louise, McCloskey, Karen, Wilson, Peter M., Longley, Daniel B., Johnston, Patrick G.
Veröffentlicht 2011

The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

von Allen, Wendy L, Jithesh, Puthen V, Oliver, Gavin R, Proutski, Irina, Longley, Daniel B, Lenz, Heinz-Josef, Proutski, Vitali, Harkin, Paul, Johnston, Patrick G
Veröffentlicht 2010

HDAC inhibition overcomes acute resistance to MEK inhibition in BRAF mutant colorectal cancer by down-regulation of c-FLIP(L)

von Carson, Robbie, Celtikci, Basak, Fenning, Cathy, Javadi, Arman, Crawford, Nyree, Carbonell, Lucia Perez, Lawler, Mark, Longley, Daniel B., Johnston, Patrick G., Van Schaeybroeck, Sandra
Veröffentlicht in Clin Cancer Res (2015)

Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711

von Crawford, Nyree, Salvucci, Manuela, Hellwig, Christian T, Lincoln, Frank A, Mooney, Ruth E, O’Connor, Carla L, Prehn, Jochen HM, Longley, Daniel B, Rehm, Markus
Veröffentlicht in Cell Death Differ (2018)

ELEVATION OF C-FLIP IN CASTRATE-RESISTANT PROSTATE CANCER ANTAGONIZES THERAPEUTIC RESPONSE TO ANDROGEN-RECEPTOR TARGETED THERAPY

von McCourt, Clare, Maxwell, Pamela, Mazzucchelli, Roberta, Montironi, Rodolfo, Scarpelli, Marina, Salto-Tellez, Manuel, O’Sullivan, Joe M., Longley, Daniel B., Waugh, David J.J.
Veröffentlicht 2012

Vorinostat Eliminates Multicellular Resistance of Mesothelioma 3D Spheroids via Restoration of Noxa Expression

von Barbone, Dario, Cheung, Priscilla, Battula, Sailaja, Busacca, Sara, Gray, Steven G., Longley, Daniel B., Bueno, Raphael, Sugarbaker, David J., Fennell, Dean A., Broaddus, V. Courtney
Veröffentlicht 2012

Identification of galanin and its receptor GalR1 as novel determinants of resistance to chemotherapy and potential biomarkers in colorectal cancer

von Stevenson, Leanne, Allen, Wendy L, Turkington, Richard, Jithesh, Puthen V, Proutski, Irina, Stewart, Gail, Lenz, Heinz-Josef, Schaeybroeck, Sandra Van, Longley, Daniel B, Johnston, Patrick G
Veröffentlicht 2012

Pharmacogenomic profiling and pathway analyses identify MAPK-dependent migration as an acute response to SN38 in p53 null and mutant colorectal cancer cells

von Allen, Wendy L., Turkington, Richard C., Stevenson, Leanne, Carson, Gail, Coyle, Vicky M., Hector, Suzanne, Dunne, Philip, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Veröffentlicht 2012

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

von Schmid, Daniela, Fay, Francois, Small, Donna M, Jaworski, Jakub, Riley, Joel S, Tegazzini, Diana, Fenning, Cathy, Jones, David S, Johnston, Patrick G, Longley, Daniel B, Scott, Christopher J
Veröffentlicht in Mol Ther (2014)

Stratified analysis reveals chemokine-like factor (CKLF) as a potential prognostic marker in the MSI-immune consensus molecular subtype CMS1 of colorectal cancer

von Dunne, Philip D., O'Reilly, Paul G., Coleman, Helen G., Gray, Ronan T., Longley, Daniel B., Johnston, Patrick G., Salto-Tellez, Manuel, Lawler, Mark, McArt, Darragh G.
Veröffentlicht in Oncotarget (2016)

Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe

von Cogo, Francesco, Poreba, Marcin, Rut, Wioletta, Groborz, Katarzyna, Smyth, Peter, Johnston, Michael C., Williams, Richard, Longley, Daniel B., Burden, Roberta E., Salvesen, Guy S., Drag, Marcin, Scott, Christopher J.
Veröffentlicht in Nanoscale (2019)