Uncovering unique roles of LPA receptors in the tumor microenvironment

by Lee, Sue-Chin, Fujiwara, Yuko, Tigyi, Gabor J.
Published in Receptors Clin Investig (2014)

Role of Autotaxin in Cancer Stem Cells

by Lee, Dongjun, Suh, Dong-Soo, Lee, Sue Chin, Tigyi, Gabor J., Kim, Jae Ho
Published in Cancer Metastasis Rev (2018)

Anti-cancer strategies targeting the autotaxin-lysophosphatidic acid receptor axis: is there a path forward?

by Tigyi, Gábor, Dacheux, Mélanie A., Lin, Kuan-Hung, Yue, Junming, Norman, Derek, Benyó, Zoltán, Lee, Sue Chin
Published in Cancer Metastasis Rev (2021)

The LPA(2) receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids

by Kuo, Bryan, Szabó, Erzsébet, Lee, Sue Chin, Balogh, Andrea, Norman, Derek, Inoue, Asuka, Ono, Yuki, Aoki, Junken, Tigyi, Gábor
Published in Cell Signal (2018)

Regulation of tumor cell – Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

by Tigyi, Gabor J., Yue, Junming, Norman, Derek D., Szabo, Erzsebet, Balogh, Andrea, Balazs, Louisa, Zhao, Guannan, Lee, Sue Chin
Published in Adv Biol Regul (2018)

Regulation of Tumor Immunity by Lysophosphatidic Acid

by Lee, Sue Chin, Dacheux, Mélanie A., Norman, Derek D., Balázs, Louisa, Torres, Raul M., Augelli-Szafran, Corinne E., Tigyi, Gábor J.
Published in Cancers (Basel) (2020)

LPAR2 receptor Activation Attenuates Radiation-Induced Disruption of Apical Junctional Complexes and Mucosal Barrier Dysfunction in Mouse Colon

by Shukla, Pradeep K., Meena, Avtar S., Gangwar, Ruchika, Szabo, Erzsebet, Balogh, Andrea, Lee, Sue Chin, Vandewalle, Alain, Tigyi, Gabor, Rao, RadhaKrishna
Published in FASEB J (2020)

Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine

by Shukla, Pradeep K., Gangwar, Ruchika, Manda, Bhargavi, Meena, Avtar S., Yadav, Nikki, Szabo, Erzsebet, Balogh, Andrea, Lee, Sue Chin, Tigyi, Gabor, Rao, RadhaKrishna
Published in Am J Physiol Gastrointest Liver Physiol (2016)

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells

by Banerjee, Souvik, Norman, Derek D., Lee, Sue Chin, Parrill, Abby L., Pham, Truc Chi T., Baker, Daniel L., Tigyi, Gabor G., Miller, Duane D.
Published in J Med Chem (2017)

Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment

by Lee, Sue Chin, Lin, Kuan-Hung, Balogh, Andrea, Norman, Derek D., Bavaria, Mitul, Kuo, Bryan, Yue, Junming, Balázs, Louisa, Benyó, Zoltán, Tigyi, Gábor
Published in Cell Signal (2020)

Molecular Modelling Guided Design, Synthesis and QSAR Analysis of New Small Molecule Non-Lipid Autotaxin Inhibitors

by Banerjee, Souvik, Norman, Derek D., Deng, Shanshan, Fakayode, Sayo, Lee, Sue Chin, Parrill, Abby L., Li, Wei, Miller, Duane D., Tigyi, Gabor J.
Published in Bioorg Chem (2020)

Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential

by Tigyi, Gabor J., Johnson, Leonard R., Lee, Sue Chin, Norman, Derek D., Szabo, Erzsebet, Balogh, Andrea, Thompson, Karin, Boler, Alyssa, McCool, W. Shannon
Published in J Lipid Res (2019)

Mitigation of Radiation Injury by Selective Stimulation of the LPA(2) Receptor

by Kiss, Gyöngyi N., Lee, Sue-Chin, Fells, James, Liu, Jiangxiong, Valentine, William J., Fujiwara, Yuko, Emmons-Thompson, Karin, Yates, Charles R., Sümegi, Balázs, Tigyi, Gabor
Published 2013

Interaction of platelet-derived autotaxin with tumor integrin α(V)β(3) controls metastasis of breast cancer cells to bone

by Leblanc, Raphael, Lee, Sue-Chin, David, Marion, Bordet, Jean-Claude, Norman, Derek D., Patil, Renukadevi, Miller, Duane, Sahay, Debashish, Ribeiro, Johnny, Clézardin, Philippe, Tigyi, Gabor J., Peyruchaud, Olivier
Published in Blood (2014)

Virtual Screening for LPA(2)-Specific Agonists Identifies a Nonlipid Compound with Antiapoptotic Actions

by Kiss, Gyöngyi N., Fells, James I., Gupte, Renuka, Lee, Sue-Chin, Liu, Jianxiong, Nusser, Nóra, Lim, Keng G., Ray, Ramesh M., Lin, Fang-Tsyr, Parrill, Abby L., Sümegi, Balázs, Miller, Duane D., Tigyi, Gabor
Published 2012

Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis

by Gotoh, Mari, Fujiwara, Yuko, Yue, Junming, Liu, Jianxiong, Lee, SueChin, Fells, James, Uchiyama, Ayako, Murakami-Murofushi, Kimiko, Kennel, Stephen, Wall, Jonathan, Patil, Renukadevi, Gupte, Renuka, Balazs, Louisa, Miller, Duane D., Tigyi, Gabor J.
Published 2012

miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer

by Zhao, Guannan, Guo, Yuqi, Chen, Zixuan, Wang, Yinan, Yang, Chuanhe, Dudas, Andrew, Du, Ziyun, Liu, Wen, Zou, Yanan, Szabo, Erzsebet, Lee, Sue-Chin, Sims, Michelle, Gu, Weiwang, Tillmanns, Todd, Pfeffer, Lawrence M., Tigyi, Gabor, Yue, Junming
Published in J Cancer Sci Ther (2015)

The autotaxin-LPA(2) GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair

by Balogh, Andrea, Shimizu, Yoshibumi, Lee, Sue Chin, Norman, Derek D., Gangwar, Ruchika, Bavaria, Mitul, Moon, ChangSuk, Shukla, Pradeep, Rao, Radakrishna, Ray, Ramesh, Naren, Anjaparavanda P., Banerje, Souvik, Miller, Duane D., Balazs, Louisa, Pelus, Louis, Tigyi, Gabor
Published in Cell Signal (2015)

Targeting the Hydrophobic Pocket of Autotaxin with Virtual Screening of Inhibitors Identifies a Common Aromatic Sulfonamide Structural Motif

by Fells, James I., Lee, Sue Chin, Norman, Derek D., Tsukahara, Ryoko, Kirby, R. Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Patil, Renukadevi, Miller, Duane D., Parrill, Abby L., Pham, Truc-Chi, Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Published 2014

Autotaxin, LPA Receptors (1 and 5) Exert Disparate Functions in Tumor Cells Versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

by Lee, Sue-Chin, Fujiwara, Yuko, Liu, Jianxiong, Yue, Junming, Shimizu, Yoshibumi, Norman, Derek D., Wang, Yaohong, Tsukahara, Ryoko, Szabo, Erzsebet, Patil, Renukadevi, Banerjee, Souvik, Miller, Duane D., Balazs, Louisa, Ghosh, Manik C., Waters, Christopher M., Oravecz, Tamas, Tigyi, Gabor J.
Published in Mol Cancer Res (2014)