Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells

Autotaxin (ATX, aka. ENPP2) is the main source of the lipid mediator lysophosphatidic acid (LPA) in biological fluids. This study reports on inhibitors of ATX derived by lead optimization of the benzene-sulfonamide in silico hit compound 3. The new analogues provide a comprehensive structure–activit...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Banerjee, Souvik, Norman, Derek D., Lee, Sue Chin, Parrill, Abby L., Pham, Truc Chi T., Baker, Daniel L., Tigyi, Gabor G., Miller, Duane D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7938327/
https://ncbi.nlm.nih.gov/pubmed/28112925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01270
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