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Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition
Autotaxin (ATX) is a ubiquitous ectoenzyme that hydrolyzes lysophosphatidylcholine (LPC) to form the bioactive lipid mediator lysophosphatidic acid (LPA). LPA activates specific G-protein coupled receptors to elicit downstream effects leading to cellular motility, survival, and invasion. Through the...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5023007/ https://ncbi.nlm.nih.gov/pubmed/27544588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.004 |
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