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Autotaxin Inhibitors: A Perspective on Initial Medicinal Chemistry Efforts
The lysophospholipase D enzyme, autotaxin (ATX), has been linked to numerous human diseases including cancer, neurophatic pain, obesity, and Alzheimer’s disease. Although the ATX protein was initially purified and characterized in 1992, a link to bioactive lipid metabolism was not made until 2002. I...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058224/ https://ncbi.nlm.nih.gov/pubmed/21047298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543776.2010.533658 |
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