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Ligand-Based Autotaxin Pharmacophore Models Reflect Structure-Based Docking Results

The autotaxin (ATX) enzyme exhibits lysophospholipase D activity responsible for the conversion of lysophosphatidyl choline to lysophosphatidic acid (LPA). ATX and LPA have been linked to the initiation of atherosclerosis, cancer invasiveness, and neuropathic pain. ATX inhibition therefore offers cu...

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Detalhes bibliográficos
Main Authors: Mize, Catrina D., Abbott, Ashley M., Gacasan, Samantha B., Parrill, Abby L., Baker, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224989/
https://ncbi.nlm.nih.gov/pubmed/21967734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2011.09.004
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