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Ligand-Based Autotaxin Pharmacophore Models Reflect Structure-Based Docking Results
The autotaxin (ATX) enzyme exhibits lysophospholipase D activity responsible for the conversion of lysophosphatidyl choline to lysophosphatidic acid (LPA). ATX and LPA have been linked to the initiation of atherosclerosis, cancer invasiveness, and neuropathic pain. ATX inhibition therefore offers cu...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3224989/ https://ncbi.nlm.nih.gov/pubmed/21967734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmgm.2011.09.004 |
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