Targeting the Hydrophobic Pocket of Autotaxin with Virtual Screening of Inhibitors Identifies a Common Aromatic Sulfonamide Structural Motif

Modulation of autotaxin (ATX), the lysophospholipase D enzyme that produces lysophosphatidic acid (LPA), with small-molecule inhibitors is a promising strategy for blocking the ATX/LPA signaling axis. While discovery campaigns have been successful in identifying ATX inhibitors, many of the reported...

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Detalhes bibliográficos
Main Authors: Fells, James I., Lee, Sue Chin, Norman, Derek D., Tsukahara, Ryoko, Kirby, R. Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Patil, Renukadevi, Miller, Duane D., Parrill, Abby L., Pham, Truc-Chi, Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048651/
https://ncbi.nlm.nih.gov/pubmed/24314137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12674
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