Loading...

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues that reduce cell migration and invasion and cause regression of orthotopic breast tumors in vivo. Two diastereoisomeric...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhang, Honglu, Xu, Xiaoyu, Gajewiak, Joanna, Tsukahara, Ryoko, Fujiwara, Yuko, Liu, Jianxiong, Fells, James I., Perygin, Donna, Parrill, Abby L., Tigyi, Gabor, Prestwich, Glenn D.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446773/
https://ncbi.nlm.nih.gov/pubmed/19509223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0302
Tags: Add Tag
No Tags, Be the first to tag this record!