Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues that reduce cell migration and invasion and cause regression of orthotopic breast tumors in vivo. Two diastereoisomeric...

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Detalhes bibliográficos
Main Authors: Zhang, Honglu, Xu, Xiaoyu, Gajewiak, Joanna, Tsukahara, Ryoko, Fujiwara, Yuko, Liu, Jianxiong, Fells, James I., Perygin, Donna, Parrill, Abby L., Tigyi, Gabor, Prestwich, Glenn D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446773/
https://ncbi.nlm.nih.gov/pubmed/19509223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0302
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