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Structure-based drug design identifies novel LPA(3) antagonists
Compound 5 ([5-(3-nitrophenoxy)-1,3-dioxo-1,3-dihydro-2-isoindol-2-yl]acetic acid) was identified as a weak selective LPA(3) antagonist (IC(50)=4504 nM) in a virtual screening effort to optimize a dual LPA(2&3) antagonist. Structure-based drug design techniques were used to prioritize similarity...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771199/ https://ncbi.nlm.nih.gov/pubmed/19800804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.09.022 |
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