Carregant...
Structure-based drug design identifies novel LPA(3) antagonists
Compound 5 ([5-(3-nitrophenoxy)-1,3-dioxo-1,3-dihydro-2-isoindol-2-yl]acetic acid) was identified as a weak selective LPA(3) antagonist (IC(50)=4504 nM) in a virtual screening effort to optimize a dual LPA(2&3) antagonist. Structure-based drug design techniques were used to prioritize similarity...
Guardat en:
| Autors principals: | , , , , |
|---|---|
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771199/ https://ncbi.nlm.nih.gov/pubmed/19800804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.09.022 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|