Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/Lysophospholipase D As an Inhibitory Surface

Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). A high-...

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Bibliografiske detaljer
Main Authors: Fells, James I., Lee, Sue Chin, Fujiwara, Yuko, Norman, Derek D., Lim, Keng Gat, Tsukahara, Ryoko, Liu, Jianxiong, Patil, Renukadevi, Miller, Duane D., Kirby, R. Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Parrill, Abby L., Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876816/
https://ncbi.nlm.nih.gov/pubmed/23793291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087080
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