Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/Lysophospholipase D As an Inhibitory Surface

Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). A high-...

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Bibliographic Details
Main Authors: Fells, James I., Lee, Sue Chin, Fujiwara, Yuko, Norman, Derek D., Lim, Keng Gat, Tsukahara, Ryoko, Liu, Jianxiong, Patil, Renukadevi, Miller, Duane D., Kirby, R. Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Parrill, Abby L., Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876816/
https://ncbi.nlm.nih.gov/pubmed/23793291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087080
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