Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/Lysophospholipase D As an Inhibitory Surface

Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). A high-...

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Bibliografiset tiedot
Päätekijät: Fells, James I., Lee, Sue Chin, Fujiwara, Yuko, Norman, Derek D., Lim, Keng Gat, Tsukahara, Ryoko, Liu, Jianxiong, Patil, Renukadevi, Miller, Duane D., Kirby, R. Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Parrill, Abby L., Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2013
Aiheet:
Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876816/
https://ncbi.nlm.nih.gov/pubmed/23793291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087080
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