Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/Lysophospholipase D As an Inhibitory Surface

Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). A high-...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Fells, James I., Lee, Sue Chin, Fujiwara, Yuko, Norman, Derek D., Lim, Keng Gat, Tsukahara, Ryoko, Liu, Jianxiong, Patil, Renukadevi, Miller, Duane D., Kirby, R. Jason, Nelson, Sandra, Seibel, William, Papoian, Ruben, Parrill, Abby L., Baker, Daniel L., Bittman, Robert, Tigyi, Gabor
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2013
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876816/
https://ncbi.nlm.nih.gov/pubmed/23793291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.087080
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi