Interaction of platelet-derived autotaxin with tumor integrin α(V)β(3) controls metastasis of breast cancer cells to bone

Autotaxin (ATX), through its lysophospholipase D activity controls physiological levels of lysophosphatidic acid (LPA) in blood. ATX is overexpressed in multiple types of cancers, and together with LPA generated during platelet activation promotes skeletal metastasis of breast cancer. However, the p...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Leblanc, Raphael, Lee, Sue-Chin, David, Marion, Bordet, Jean-Claude, Norman, Derek D., Patil, Renukadevi, Miller, Duane, Sahay, Debashish, Ribeiro, Johnny, Clézardin, Philippe, Tigyi, Gabor J., Peyruchaud, Olivier
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2014
Sujets:
Platelets and Thrombopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231421/
https://ncbi.nlm.nih.gov/pubmed/25277122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-568683
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