LPAR2 receptor Activation Attenuates Radiation-Induced Disruption of Apical Junctional Complexes and Mucosal Barrier Dysfunction in Mouse Colon

The tight junction (TJ) and barrier function of colonic epithelium is highly sensitive to ionizing radiation. We evaluated the effect of lysophosphatidic acid (LPA) and its analog, Radioprotein-1, on γ-radiation-induced colonic epithelial barrier dysfunction using Caco-2 and m-IC(C12) cell monolayer...

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Veröffentlicht in:FASEB J
Hauptverfasser: Shukla, Pradeep K., Meena, Avtar S., Gangwar, Ruchika, Szabo, Erzsebet, Balogh, Andrea, Lee, Sue Chin, Vandewalle, Alain, Tigyi, Gabor, Rao, RadhaKrishna
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7725959/
https://ncbi.nlm.nih.gov/pubmed/32654268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202000544R
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