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Calcium Channels and Oxidative Stress Mediate a Synergistic Disruption of Tight Junctions by Ethanol and Acetaldehyde in Caco-2 Cell Monolayers

Ethanol is metabolized into acetaldehyde in most tissues. In this study, we investigated the synergistic effect of ethanol and acetaldehyde on the tight junction integrity in Caco-2 cell monolayers. Expression of alcohol dehydrogenase sensitized Caco-2 cells to ethanol-induced tight junction disrupt...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Samak, Geetha, Gangwar, Ruchika, Meena, Avtar S., Rao, Roshan G., Shukla, Pradeep K., Manda, Bhargavi, Narayanan, Damodaran, Jaggar, Jonathan H., Rao, RadhaKrishna
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153649/
https://ncbi.nlm.nih.gov/pubmed/27958326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38899
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