Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq

por Lazzarotto, Cicera R., Nguyen, Nhu T., Tang, Xing, Malagon-Lopez, Jose, Guo, Jimmy, Aryee, Martin J., Joung, J. Keith, Tsai, Shengdar Q.
Publicado en Nat Protoc (2018)

Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9

por Pinzon-Arteaga, Carlos, Snyder, Matthew D., Lazzarotto, Cicera R., Moreno, Nicolas F., Juras, Rytis, Raudsepp, Terje, Golding, Michael C., Varner, Dickson D., Long, Charles R.
Publicado en Sci Rep (2020)

Susceptibility of Mice to Trypanosoma evansi Treated with Human Plasma Containing Different Concentrations of Apolipoprotein L-1

por Da Silva, Aleksandro S., Fanfa, Vinicius R., Otto, Mateus A., Gressler, Lucas T., Tavares, Kaio C.S., Lazzarotto, Cícera R., Tonin, Alexandre A., Miletti, Luiz C., Duarte, Marta M.M.F., Monteiro, Silvia G.
Publicado 2011

CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity

por Lazzarotto, Cicera R., Malinin, Nikolay L., Li, Yichao, Zhang, Ruochi, Yang, Yang, Lee, GaHyun, Cowley, Eleanor, He, Yanghua, Lan, Xin, Jividen, Kasey, Katta, Varun, Kolmakova, Natalia G., Petersen, Christopher T., Qi, Qian, Strelcov, Evgheni, Maragh, Samantha, Krenciute, Giedre, Ma, Jian, Cheng, Yong, Tsai, Shengdar Q.
Publicado en Nat Biotechnol (2020)

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

por Gao, Pan, Lyu, Qing, Ghanam, Amr R., Lazzarotto, Cicera R., Newby, Gregory A., Zhang, Wei, Choi, Mihyun, Slivano, Orazio J., Holden, Kevin, Walker, John A., Kadina, Anastasia P., Munroe, Rob J., Abratte, Christian M., Schimenti, John C., Liu, David R., Tsai, Shengdar Q., Long, Xiaochun, Miano, Joseph M.
Publicado en Genome Biol (2021)

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

por Kim, Miriam Y, Yu, Kyung-Rok, Kenderian, Saad S, Ruella, Marco, Chen, Shirley, Shin, Tae-Hoon, Aljanahi, Aisha A, Schreeder, Daniel, Klichinsky, Michael, Shestova, Olga, Kozlowski, Miroslaw S, Cummins, Katherine D, Shan, Xinhe, Shestov, Maksim, Bagg, Adam, Morrissette, Jennifer JD, Sekhri, Palak, Lazzarotto, Cicera R, Calvo, Katherine R, Kuhns, Douglas B, Donahue, Robert E, Behbehani, Gregory K, Tsai, Shengdar Q, Dunbar, Cynthia E, Gill, Saar
Publicado en Cell (2018)

Highly efficient therapeutic gene editing of human hematopoietic stem cells

por Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P., Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R., Clement, M. Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Shen, Anne H., Ren, Chunyan, Esrick, Erica B., Manis, John P., Dorfman, David M., Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q., Wolfe, Scot A., Bauer, Daniel E.
Publicado en Nat Med (2019)

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

por De Ravin, Suk See, Brault, Julie, Meis, Ronald J., Liu, Siyuan, Li, Linhong, Pavel-Dinu, Mara, Lazzarotto, Cicera R., Liu, Taylor, Koontz, Sherry M., Choi, Uimook, Sweeney, Colin L., Theobald, Narda, Lee, GaHyun, Clark, Aaron B., Burkett, Sandra S., Kleinstiver, Benjamin P., Porteus, Matthew H., Tsai, Shengdar, Kuhns, Douglas B., Dahl, Gary A., Headey, Stephen, Wu, Xiaolin, Malech, Harry L.
Publicado en Blood (2021)

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

por Métais, Jean-Yves, Doerfler, Phillip A., Mayuranathan, Thiyagaraj, Bauer, Daniel E., Fowler, Stephanie C., Hsieh, Matthew M., Katta, Varun, Keriwala, Sagar, Lazzarotto, Cicera R., Luk, Kevin, Neel, Michael D., Perry, S. Scott, Peters, Samuel T., Porter, Shaina N., Ryu, Byoung Y., Sharma, Akshay, Shea, Devlin, Tisdale, John F., Uchida, Naoya, Wolfe, Scot A., Woodard, Kaitly J., Wu, Yuxuan, Yao, Yu, Zeng, Jing, Pruett-Miller, Shondra, Tsai, Shengdar Q., Weiss, Mitchell J.
Publicado en Blood Adv (2019)

BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity

por Demirci, Selami, Zeng, Jing, Wu, Yuxuan, Uchida, Naoya, Shen, Anne H., Pellin, Danilo, Gamer, Jackson, Yapundich, Morgan, Drysdale, Claire, Bonanno, Jasmine, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Engels, Theresa, Donahue, Robert E., Haro-Mora, Juan J., Leonard, Alexis, Nassehi, Tina, Luk, Kevin, Porter, Shaina N., Lazzarotto, Cicera R., Tsai, Shengdar Q., Weiss, Mitchell J., Pruett-Miller, Shondra M., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F.
Publicado en J Clin Invest (2020)

Base editing of hematopoietic stem cells rescues sickle cell disease in mice

por Newby, Gregory A., Yen, Jonathan S., Woodard, Kaitly J., Mayuranathan, Thiyagaraj, Lazzarotto, Cicera R., Li, Yichao, Sheppard-Tillman, Heather, Porter, Shaina N., Yao, Yu, Mayberry, Kalin, Everette, Kelcee A., Jang, Yoonjeong, Podracky, Christopher J., Thaman, Elizabeth, Lechauve, Christophe, Sharma, Akshay, Henderson, Jordana M., Richter, Michelle F., Zhao, Kevin T., Miller, Shannon M., Wang, Tina, Koblan, Luke W., McCaffrey, Anton P., Tisdale, John F., Kalfa, Theodosia A., Pruett-Miller, Shondra M., Tsai, Shengdar Q., Weiss, Mitchell J., Liu, David R.
Publicado en Nature (2021)