Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq

Por Lazzarotto, Cicera R., Nguyen, Nhu T., Tang, Xing, Malagon-Lopez, Jose, Guo, Jimmy, Aryee, Martin J., Joung, J. Keith, Tsai, Shengdar Q.
Publicado no Nat Protoc (2018)

Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9

Por Pinzon-Arteaga, Carlos, Snyder, Matthew D., Lazzarotto, Cicera R., Moreno, Nicolas F., Juras, Rytis, Raudsepp, Terje, Golding, Michael C., Varner, Dickson D., Long, Charles R.
Publicado no Sci Rep (2020)

Susceptibility of Mice to Trypanosoma evansi Treated with Human Plasma Containing Different Concentrations of Apolipoprotein L-1

Por Da Silva, Aleksandro S., Fanfa, Vinicius R., Otto, Mateus A., Gressler, Lucas T., Tavares, Kaio C.S., Lazzarotto, Cícera R., Tonin, Alexandre A., Miletti, Luiz C., Duarte, Marta M.M.F., Monteiro, Silvia G.
Publicado em 2011

CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity

Por Lazzarotto, Cicera R., Malinin, Nikolay L., Li, Yichao, Zhang, Ruochi, Yang, Yang, Lee, GaHyun, Cowley, Eleanor, He, Yanghua, Lan, Xin, Jividen, Kasey, Katta, Varun, Kolmakova, Natalia G., Petersen, Christopher T., Qi, Qian, Strelcov, Evgheni, Maragh, Samantha, Krenciute, Giedre, Ma, Jian, Cheng, Yong, Tsai, Shengdar Q.
Publicado no Nat Biotechnol (2020)

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

Por Kim, Miriam Y, Yu, Kyung-Rok, Kenderian, Saad S, Ruella, Marco, Chen, Shirley, Shin, Tae-Hoon, Aljanahi, Aisha A, Schreeder, Daniel, Klichinsky, Michael, Shestova, Olga, Kozlowski, Miroslaw S, Cummins, Katherine D, Shan, Xinhe, Shestov, Maksim, Bagg, Adam, Morrissette, Jennifer JD, Sekhri, Palak, Lazzarotto, Cicera R, Calvo, Katherine R, Kuhns, Douglas B, Donahue, Robert E, Behbehani, Gregory K, Tsai, Shengdar Q, Dunbar, Cynthia E, Gill, Saar
Publicado no Cell (2018)

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Por Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P., Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R., Clement, M. Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Shen, Anne H., Ren, Chunyan, Esrick, Erica B., Manis, John P., Dorfman, David M., Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q., Wolfe, Scot A., Bauer, Daniel E.
Publicado no Nat Med (2019)

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

Por Métais, Jean-Yves, Doerfler, Phillip A., Mayuranathan, Thiyagaraj, Bauer, Daniel E., Fowler, Stephanie C., Hsieh, Matthew M., Katta, Varun, Keriwala, Sagar, Lazzarotto, Cicera R., Luk, Kevin, Neel, Michael D., Perry, S. Scott, Peters, Samuel T., Porter, Shaina N., Ryu, Byoung Y., Sharma, Akshay, Shea, Devlin, Tisdale, John F., Uchida, Naoya, Wolfe, Scot A., Woodard, Kaitly J., Wu, Yuxuan, Yao, Yu, Zeng, Jing, Pruett-Miller, Shondra, Tsai, Shengdar Q., Weiss, Mitchell J.
Publicado no Blood Adv (2019)

BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity

Por Demirci, Selami, Zeng, Jing, Wu, Yuxuan, Uchida, Naoya, Shen, Anne H., Pellin, Danilo, Gamer, Jackson, Yapundich, Morgan, Drysdale, Claire, Bonanno, Jasmine, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Engels, Theresa, Donahue, Robert E., Haro-Mora, Juan J., Leonard, Alexis, Nassehi, Tina, Luk, Kevin, Porter, Shaina N., Lazzarotto, Cicera R., Tsai, Shengdar Q., Weiss, Mitchell J., Pruett-Miller, Shondra M., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F.
Publicado no J Clin Invest (2020)