Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

The absence of cancer-restricted surface markers is a major impediment to antigen-specific immunotherapy using chimeric antigen receptor (CAR) T cells. For example, targeting the canonical myeloid marker CD33 in acute myeloid leukemia (AML) results in toxicity from destruction of normal myeloid cell...

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Publicado no:Cell
Main Authors: Kim, Miriam Y, Yu, Kyung-Rok, Kenderian, Saad S, Ruella, Marco, Chen, Shirley, Shin, Tae-Hoon, Aljanahi, Aisha A, Schreeder, Daniel, Klichinsky, Michael, Shestova, Olga, Kozlowski, Miroslaw S, Cummins, Katherine D, Shan, Xinhe, Shestov, Maksim, Bagg, Adam, Morrissette, Jennifer JD, Sekhri, Palak, Lazzarotto, Cicera R, Calvo, Katherine R, Kuhns, Douglas B, Donahue, Robert E, Behbehani, Gregory K, Tsai, Shengdar Q, Dunbar, Cynthia E, Gill, Saar
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6003425/
https://ncbi.nlm.nih.gov/pubmed/29856956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.05.013
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