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Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
We and others previously reported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in preclinical human acute myeloid leukemia (AML) models at the cost of severe hematologic toxicity. This observation raises concern for potential myeloablation in patients with...
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Publicado no: | Blood |
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Main Authors: | , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society of Hematology
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409446/ https://ncbi.nlm.nih.gov/pubmed/28246194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-736041 |
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