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Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia
We and others previously reported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in preclinical human acute myeloid leukemia (AML) models at the cost of severe hematologic toxicity. This observation raises concern for potential myeloablation in patients with...
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| 出版年: | Blood |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409446/ https://ncbi.nlm.nih.gov/pubmed/28246194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-736041 |
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