Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia

We and others previously reported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in preclinical human acute myeloid leukemia (AML) models at the cost of severe hematologic toxicity. This observation raises concern for potential myeloablation in patients with...

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Detalles Bibliográficos
Publicado en:Blood
Autores principales: Tasian, Sarah K., Kenderian, Saad S., Shen, Feng, Ruella, Marco, Shestova, Olga, Kozlowski, Miroslaw, Li, Yong, Schrank-Hacker, April, Morrissette, Jennifer J. D., Carroll, Martin, June, Carl H., Grupp, Stephan A., Gill, Saar
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2017
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409446/
https://ncbi.nlm.nih.gov/pubmed/28246194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-736041
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