Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia

We and others previously reported potent antileukemia efficacy of CD123-redirected chimeric antigen receptor (CAR) T cells in preclinical human acute myeloid leukemia (AML) models at the cost of severe hematologic toxicity. This observation raises concern for potential myeloablation in patients with...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Tasian, Sarah K., Kenderian, Saad S., Shen, Feng, Ruella, Marco, Shestova, Olga, Kozlowski, Miroslaw, Li, Yong, Schrank-Hacker, April, Morrissette, Jennifer J. D., Carroll, Martin, June, Carl H., Grupp, Stephan A., Gill, Saar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Immunobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409446/
https://ncbi.nlm.nih.gov/pubmed/28246194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-736041
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge