Immunoresponse to Gene-Modified Hematopoietic Stem Cells

por Drysdale, Claire M., Tisdale, John F., Uchida, Naoya
Publicado no Mol Ther Methods Clin Dev (2019)

High-Efficiency Lentiviral Transduction of Human CD34(+) Cells in High-Density Culture with Poloxamer and Prostaglandin E2

por Uchida, Naoya, Nassehi, Tina, Drysdale, Claire M., Gamer, Jackson, Yapundich, Morgan, Demirci, Selami, Haro-Mora, Juan J., Leonard, Alexis, Hsieh, Matthew M., Tisdale, John F.
Publicado no Mol Ther Methods Clin Dev (2019)

Low-Dose Busulfan Reduces Human CD34(+) Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice

por Leonard, Alexis, Yapundich, Morgan, Nassehi, Tina, Gamer, Jackson, Drysdale, Claire M., Haro-Mora, Juan J., Demirci, Selami, Hsieh, Matthew M., Uchida, Naoya, Tisdale, John F.
Publicado no Mol Ther Methods Clin Dev (2019)

βT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells

por Demirci, Selami, Gudmundsdottir, Bjorg, Li, Quan, Haro-Mora, Juan J., Nassehi, Tina, Drysdale, Claire, Yapundich, Morgan, Gamer, Jackson, Seifuddin, Fayaz, Tisdale, John F., Uchida, Naoya
Publicado no Mol Ther Methods Clin Dev (2020)

Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

por Demirci, Selami, Haro-Mora, Juan J., Leonard, Alexis, Drysdale, Claire, Malide, Daniela, Keyvanfar, Keyvan, Essawi, Khaled, Vizcardo, Raul, Tamaoki, Naritaka, Restifo, Nicholas P., Tisdale, John F., Uchida, Naoya
Publicado no Stem Cell Res Ther (2020)

Correction to: Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

por Demirci, Selami, Haro-Mora, Juan J., Leonard, Alexis, Drysdale, Claire, Malide, Daniela, Keyvanfar, Keyvan, Essawi, Khaled, Vizcardo, Raul, Tamaoki, Naritaka, Restifo, Nicholas P., Tisdale, John F., Uchida, Naoya
Publicado no Stem Cell Res Ther (2020)

Cas9 protein delivery non-integrating lentiviral vectors for gene correction in sickle cell disease

por Uchida, Naoya, Drysdale, Claire M., Nassehi, Tina, Gamer, Jackson, Yapundich, Morgan, DiNicola, Julia, Shibata, Yoshitaka, Hinds, Malikiya, Gudmundsdottir, Bjorg, Haro-Mora, Juan J., Demirci, Selami, Tisdale, John F.
Publicado no Mol Ther Methods Clin Dev (2021)

Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model

por Uchida, Naoya, Nassehi, Tina, Drysdale, Claire M., Gamer, Jackson, Yapundich, Morgan, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel, Hsieh, Matthew M., Donahue, Robert E., Dunbar, Cynthia E., Kean, Leslie S., Tisdale, John F.
Publicado no Mol Ther (2019)

Preclinical evaluation for engraftment of CD34(+) cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models

por Uchida, Naoya, Li, Linhong, Nassehi, Tina, Drysdale, Claire M., Yapundich, Morgan, Gamer, Jackson, Haro-Mora, Juan J., Demirci, Selami, Leonard, Alexis, Bonifacino, Aylin C., Krouse, Allen E., Linde, N. Seth, Allen, Cornell, Peshwa, Madhusudan V., De Ravin, Suk See, Donahue, Robert E., Malech, Harry L., Tisdale, John F.
Publicado no Cell Rep Med (2021)

BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity

por Demirci, Selami, Zeng, Jing, Wu, Yuxuan, Uchida, Naoya, Shen, Anne H., Pellin, Danilo, Gamer, Jackson, Yapundich, Morgan, Drysdale, Claire, Bonanno, Jasmine, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Engels, Theresa, Donahue, Robert E., Haro-Mora, Juan J., Leonard, Alexis, Nassehi, Tina, Luk, Kevin, Porter, Shaina N., Lazzarotto, Cicera R., Tsai, Shengdar Q., Weiss, Mitchell J., Pruett-Miller, Shondra M., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F.
Publicado no J Clin Invest (2020)