Low-Dose Busulfan Reduces Human CD34(+) Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice

Humanized animal models are central to efforts aimed at improving hematopoietic stem cell (HSC) transplantation with or without genetic modification. Human cell engraftment is feasible in immunodeficient mice; however, high HSC doses and conditioning limit broad use of xenograft models. We assessed...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Leonard, Alexis, Yapundich, Morgan, Nassehi, Tina, Gamer, Jackson, Drysdale, Claire M., Haro-Mora, Juan J., Demirci, Selami, Hsieh, Matthew M., Uchida, Naoya, Tisdale, John F.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909187/
https://ncbi.nlm.nih.gov/pubmed/31890735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.10.017
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