Busulfan Combined with Immunosuppression Allows Efficient Engraftment of Gene-Modified Cells in a Rhesus Macaque Model

Busulfan conditioning is utilized for hematopoietic stem cell (HSC) depletion in the context of HSC gene-therapy conditioning but may result in insufficient immunosuppression. In this study, we evaluated whether additional immunosuppression is required for efficient engraftment of gene-modified cell...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Uchida, Naoya, Nassehi, Tina, Drysdale, Claire M., Gamer, Jackson, Yapundich, Morgan, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel, Hsieh, Matthew M., Donahue, Robert E., Dunbar, Cynthia E., Kean, Leslie S., Tisdale, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731177/
https://ncbi.nlm.nih.gov/pubmed/31253582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.05.022
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