Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model

Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) gene therapy applications. However, low gene marking was previously observed in gene therapy trials, suggesting that RIC might be insufficient for (i) opening niches for efficient engraftment and/or (ii) inducing imm...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Uchida, Naoya, Weitzel, R Patrick, Shvygin, Anna, Skala, Luke P, Raines, Lydia, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Donahue, Robert E, Tisdale, John F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022796/
https://ncbi.nlm.nih.gov/pubmed/27652288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.59
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