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Total body irradiation must be delivered at high dose for efficient engraftment and tolerance in a rhesus stem cell gene therapy model

Reduced intensity conditioning (RIC) is desirable for hematopoietic stem cell (HSC) gene therapy applications. However, low gene marking was previously observed in gene therapy trials, suggesting that RIC might be insufficient for (i) opening niches for efficient engraftment and/or (ii) inducing imm...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther Methods Clin Dev
Asıl Yazarlar: Uchida, Naoya, Weitzel, R Patrick, Shvygin, Anna, Skala, Luke P, Raines, Lydia, Bonifacino, Aylin C, Krouse, Allen E, Metzger, Mark E, Donahue, Robert E, Tisdale, John F
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5022796/
https://ncbi.nlm.nih.gov/pubmed/27652288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.59
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