Low-Dose Busulfan Reduces Human CD34(+) Cell Doses Required for Engraftment in c-kit Mutant Immunodeficient Mice

Humanized animal models are central to efforts aimed at improving hematopoietic stem cell (HSC) transplantation with or without genetic modification. Human cell engraftment is feasible in immunodeficient mice; however, high HSC doses and conditioning limit broad use of xenograft models. We assessed...

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Udgivet i:Mol Ther Methods Clin Dev
Main Authors: Leonard, Alexis, Yapundich, Morgan, Nassehi, Tina, Gamer, Jackson, Drysdale, Claire M., Haro-Mora, Juan J., Demirci, Selami, Hsieh, Matthew M., Uchida, Naoya, Tisdale, John F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909187/
https://ncbi.nlm.nih.gov/pubmed/31890735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.10.017
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