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Immunoresponse to Gene-Modified Hematopoietic Stem Cells

Gene transfer to and correction of hematopoietic stem cells (HSCs) are ideal strategies to cure a number of congenital and acquired disorders. However, transgene products may trigger immunological rejection of modified cells, limiting their therapeutic benefits. Preclinical and clinical data indicat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Drysdale, Claire M., Tisdale, John F., Uchida, Naoya
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859277/
https://ncbi.nlm.nih.gov/pubmed/31763350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.10.010
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