Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq

le Lazzarotto, Cicera R., Nguyen, Nhu T., Tang, Xing, Malagon-Lopez, Jose, Guo, Jimmy, Aryee, Martin J., Joung, J. Keith, Tsai, Shengdar Q.
Foilsithe in Nat Protoc (2018)

Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9

le Pinzon-Arteaga, Carlos, Snyder, Matthew D., Lazzarotto, Cicera R., Moreno, Nicolas F., Juras, Rytis, Raudsepp, Terje, Golding, Michael C., Varner, Dickson D., Long, Charles R.
Foilsithe in Sci Rep (2020)

Susceptibility of Mice to Trypanosoma evansi Treated with Human Plasma Containing Different Concentrations of Apolipoprotein L-1

le Da Silva, Aleksandro S., Fanfa, Vinicius R., Otto, Mateus A., Gressler, Lucas T., Tavares, Kaio C.S., Lazzarotto, Cícera R., Tonin, Alexandre A., Miletti, Luiz C., Duarte, Marta M.M.F., Monteiro, Silvia G.
Foilsithe 2011

CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity

le Lazzarotto, Cicera R., Malinin, Nikolay L., Li, Yichao, Zhang, Ruochi, Yang, Yang, Lee, GaHyun, Cowley, Eleanor, He, Yanghua, Lan, Xin, Jividen, Kasey, Katta, Varun, Kolmakova, Natalia G., Petersen, Christopher T., Qi, Qian, Strelcov, Evgheni, Maragh, Samantha, Krenciute, Giedre, Ma, Jian, Cheng, Yong, Tsai, Shengdar Q.
Foilsithe in Nat Biotechnol (2020)

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

le Gao, Pan, Lyu, Qing, Ghanam, Amr R., Lazzarotto, Cicera R., Newby, Gregory A., Zhang, Wei, Choi, Mihyun, Slivano, Orazio J., Holden, Kevin, Walker, John A., Kadina, Anastasia P., Munroe, Rob J., Abratte, Christian M., Schimenti, John C., Liu, David R., Tsai, Shengdar Q., Long, Xiaochun, Miano, Joseph M.
Foilsithe in Genome Biol (2021)

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

le Kim, Miriam Y, Yu, Kyung-Rok, Kenderian, Saad S, Ruella, Marco, Chen, Shirley, Shin, Tae-Hoon, Aljanahi, Aisha A, Schreeder, Daniel, Klichinsky, Michael, Shestova, Olga, Kozlowski, Miroslaw S, Cummins, Katherine D, Shan, Xinhe, Shestov, Maksim, Bagg, Adam, Morrissette, Jennifer JD, Sekhri, Palak, Lazzarotto, Cicera R, Calvo, Katherine R, Kuhns, Douglas B, Donahue, Robert E, Behbehani, Gregory K, Tsai, Shengdar Q, Dunbar, Cynthia E, Gill, Saar
Foilsithe in Cell (2018)

Highly efficient therapeutic gene editing of human hematopoietic stem cells

le Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P., Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R., Clement, M. Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Shen, Anne H., Ren, Chunyan, Esrick, Erica B., Manis, John P., Dorfman, David M., Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q., Wolfe, Scot A., Bauer, Daniel E.
Foilsithe in Nat Med (2019)

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

le De Ravin, Suk See, Brault, Julie, Meis, Ronald J., Liu, Siyuan, Li, Linhong, Pavel-Dinu, Mara, Lazzarotto, Cicera R., Liu, Taylor, Koontz, Sherry M., Choi, Uimook, Sweeney, Colin L., Theobald, Narda, Lee, GaHyun, Clark, Aaron B., Burkett, Sandra S., Kleinstiver, Benjamin P., Porteus, Matthew H., Tsai, Shengdar, Kuhns, Douglas B., Dahl, Gary A., Headey, Stephen, Wu, Xiaolin, Malech, Harry L.
Foilsithe in Blood (2021)

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

le Métais, Jean-Yves, Doerfler, Phillip A., Mayuranathan, Thiyagaraj, Bauer, Daniel E., Fowler, Stephanie C., Hsieh, Matthew M., Katta, Varun, Keriwala, Sagar, Lazzarotto, Cicera R., Luk, Kevin, Neel, Michael D., Perry, S. Scott, Peters, Samuel T., Porter, Shaina N., Ryu, Byoung Y., Sharma, Akshay, Shea, Devlin, Tisdale, John F., Uchida, Naoya, Wolfe, Scot A., Woodard, Kaitly J., Wu, Yuxuan, Yao, Yu, Zeng, Jing, Pruett-Miller, Shondra, Tsai, Shengdar Q., Weiss, Mitchell J.
Foilsithe in Blood Adv (2019)

BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity

le Demirci, Selami, Zeng, Jing, Wu, Yuxuan, Uchida, Naoya, Shen, Anne H., Pellin, Danilo, Gamer, Jackson, Yapundich, Morgan, Drysdale, Claire, Bonanno, Jasmine, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Engels, Theresa, Donahue, Robert E., Haro-Mora, Juan J., Leonard, Alexis, Nassehi, Tina, Luk, Kevin, Porter, Shaina N., Lazzarotto, Cicera R., Tsai, Shengdar Q., Weiss, Mitchell J., Pruett-Miller, Shondra M., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F.
Foilsithe in J Clin Invest (2020)

Base editing of hematopoietic stem cells rescues sickle cell disease in mice

le Newby, Gregory A., Yen, Jonathan S., Woodard, Kaitly J., Mayuranathan, Thiyagaraj, Lazzarotto, Cicera R., Li, Yichao, Sheppard-Tillman, Heather, Porter, Shaina N., Yao, Yu, Mayberry, Kalin, Everette, Kelcee A., Jang, Yoonjeong, Podracky, Christopher J., Thaman, Elizabeth, Lechauve, Christophe, Sharma, Akshay, Henderson, Jordana M., Richter, Michelle F., Zhao, Kevin T., Miller, Shannon M., Wang, Tina, Koblan, Luke W., McCaffrey, Anton P., Tisdale, John F., Kalfa, Theodosia A., Pruett-Miller, Shondra M., Tsai, Shengdar Q., Weiss, Mitchell J., Liu, David R.
Foilsithe in Nature (2021)