Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq

per Lazzarotto, Cicera R., Nguyen, Nhu T., Tang, Xing, Malagon-Lopez, Jose, Guo, Jimmy, Aryee, Martin J., Joung, J. Keith, Tsai, Shengdar Q.
Publicat a Nat Protoc (2018)

Efficient correction of a deleterious point mutation in primary horse fibroblasts with CRISPR-Cas9

per Pinzon-Arteaga, Carlos, Snyder, Matthew D., Lazzarotto, Cicera R., Moreno, Nicolas F., Juras, Rytis, Raudsepp, Terje, Golding, Michael C., Varner, Dickson D., Long, Charles R.
Publicat a Sci Rep (2020)

Susceptibility of Mice to Trypanosoma evansi Treated with Human Plasma Containing Different Concentrations of Apolipoprotein L-1

per Da Silva, Aleksandro S., Fanfa, Vinicius R., Otto, Mateus A., Gressler, Lucas T., Tavares, Kaio C.S., Lazzarotto, Cícera R., Tonin, Alexandre A., Miletti, Luiz C., Duarte, Marta M.M.F., Monteiro, Silvia G.
Publicat 2011

CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity

per Lazzarotto, Cicera R., Malinin, Nikolay L., Li, Yichao, Zhang, Ruochi, Yang, Yang, Lee, GaHyun, Cowley, Eleanor, He, Yanghua, Lan, Xin, Jividen, Kasey, Katta, Varun, Kolmakova, Natalia G., Petersen, Christopher T., Qi, Qian, Strelcov, Evgheni, Maragh, Samantha, Krenciute, Giedre, Ma, Jian, Cheng, Yong, Tsai, Shengdar Q.
Publicat a Nat Biotechnol (2020)

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

per Gao, Pan, Lyu, Qing, Ghanam, Amr R., Lazzarotto, Cicera R., Newby, Gregory A., Zhang, Wei, Choi, Mihyun, Slivano, Orazio J., Holden, Kevin, Walker, John A., Kadina, Anastasia P., Munroe, Rob J., Abratte, Christian M., Schimenti, John C., Liu, David R., Tsai, Shengdar Q., Long, Xiaochun, Miano, Joseph M.
Publicat a Genome Biol (2021)

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

per Kim, Miriam Y, Yu, Kyung-Rok, Kenderian, Saad S, Ruella, Marco, Chen, Shirley, Shin, Tae-Hoon, Aljanahi, Aisha A, Schreeder, Daniel, Klichinsky, Michael, Shestova, Olga, Kozlowski, Miroslaw S, Cummins, Katherine D, Shan, Xinhe, Shestov, Maksim, Bagg, Adam, Morrissette, Jennifer JD, Sekhri, Palak, Lazzarotto, Cicera R, Calvo, Katherine R, Kuhns, Douglas B, Donahue, Robert E, Behbehani, Gregory K, Tsai, Shengdar Q, Dunbar, Cynthia E, Gill, Saar
Publicat a Cell (2018)

Highly efficient therapeutic gene editing of human hematopoietic stem cells

per Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P., Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R., Clement, M. Kendell, Cole, Mitchel A., Luk, Kevin, Baricordi, Cristina, Shen, Anne H., Ren, Chunyan, Esrick, Erica B., Manis, John P., Dorfman, David M., Williams, David A., Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q., Wolfe, Scot A., Bauer, Daniel E.
Publicat a Nat Med (2019)

Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells

per De Ravin, Suk See, Brault, Julie, Meis, Ronald J., Liu, Siyuan, Li, Linhong, Pavel-Dinu, Mara, Lazzarotto, Cicera R., Liu, Taylor, Koontz, Sherry M., Choi, Uimook, Sweeney, Colin L., Theobald, Narda, Lee, GaHyun, Clark, Aaron B., Burkett, Sandra S., Kleinstiver, Benjamin P., Porteus, Matthew H., Tsai, Shengdar, Kuhns, Douglas B., Dahl, Gary A., Headey, Stephen, Wu, Xiaolin, Malech, Harry L.
Publicat a Blood (2021)

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

per Métais, Jean-Yves, Doerfler, Phillip A., Mayuranathan, Thiyagaraj, Bauer, Daniel E., Fowler, Stephanie C., Hsieh, Matthew M., Katta, Varun, Keriwala, Sagar, Lazzarotto, Cicera R., Luk, Kevin, Neel, Michael D., Perry, S. Scott, Peters, Samuel T., Porter, Shaina N., Ryu, Byoung Y., Sharma, Akshay, Shea, Devlin, Tisdale, John F., Uchida, Naoya, Wolfe, Scot A., Woodard, Kaitly J., Wu, Yuxuan, Yao, Yu, Zeng, Jing, Pruett-Miller, Shondra, Tsai, Shengdar Q., Weiss, Mitchell J.
Publicat a Blood Adv (2019)

BCL11A enhancer–edited hematopoietic stem cells persist in rhesus monkeys without toxicity

per Demirci, Selami, Zeng, Jing, Wu, Yuxuan, Uchida, Naoya, Shen, Anne H., Pellin, Danilo, Gamer, Jackson, Yapundich, Morgan, Drysdale, Claire, Bonanno, Jasmine, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Engels, Theresa, Donahue, Robert E., Haro-Mora, Juan J., Leonard, Alexis, Nassehi, Tina, Luk, Kevin, Porter, Shaina N., Lazzarotto, Cicera R., Tsai, Shengdar Q., Weiss, Mitchell J., Pruett-Miller, Shondra M., Wolfe, Scot A., Bauer, Daniel E., Tisdale, John F.
Publicat a J Clin Invest (2020)

Base editing of hematopoietic stem cells rescues sickle cell disease in mice

per Newby, Gregory A., Yen, Jonathan S., Woodard, Kaitly J., Mayuranathan, Thiyagaraj, Lazzarotto, Cicera R., Li, Yichao, Sheppard-Tillman, Heather, Porter, Shaina N., Yao, Yu, Mayberry, Kalin, Everette, Kelcee A., Jang, Yoonjeong, Podracky, Christopher J., Thaman, Elizabeth, Lechauve, Christophe, Sharma, Akshay, Henderson, Jordana M., Richter, Michelle F., Zhao, Kevin T., Miller, Shannon M., Wang, Tina, Koblan, Luke W., McCaffrey, Anton P., Tisdale, John F., Kalfa, Theodosia A., Pruett-Miller, Shondra M., Tsai, Shengdar Q., Weiss, Mitchell J., Liu, David R.
Publicat a Nature (2021)