Regulation and aggregation of intrinsically disordered peptides

Por Levine, Zachary A., Larini, Luca, LaPointe, Nichole E., Feinstein, Stuart C., Shea, Joan-Emma
Publicado no Proc Natl Acad Sci U S A (2015)

Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neu...

Por LaPointe, Nichole E., Morfini, Gerardo, Brady, Scott T., Feinstein, Stuart C., Wilson, Leslie, Jordan, Mary Ann
Publicado em 2013

The Neuroprotective Peptide NAP Does Not Directly Affect Polymerization or Dynamics of Reconstituted Neural Microtubules

Por Yenjerla, Mythili, LaPointe, Nichole E, Lopus, Manu, Cox, Corey, Jordan, Mary Ann, Feinstein, Stuart C, Wilson, Leslie
Publicado em 2010

Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro

Por LaPointe, Nichole E., Horowitz, Peleg M., Guillozet-Bongaarts, Angela L., Silva, Andres, Andreadis, Athena, Binder, Lester I.
Publicado em 2009

The Amino Terminus of Tau Inhibits Kinesin-Dependent Axonal Transport: Implications for Filament Toxicity

Por LaPointe, Nichole E., Morfini, Gerardo, Pigino, Gustavo, Gaisina, Irina N., Kozikowski, Alan P., Binder, Lester I., Brady, Scott T.
Publicado em 2009

Initiation of Assembly of Tau(273–284) and its ΔK280 Mutant: An Experimental and Computational Study()

Por Larini, Luca, Gessel, Megan Murray, LaPointe, Nichole E., Do, Thanh D., Bowers, Michael T., Feinstein, Stuart C., Shea, Joan-Emma
Publicado em 2013

Tau Aggregation Propensity Engrained in Its Solution State

Por Eschmann, Neil A., Do, Thanh D., LaPointe, Nichole E., Shea, Joan-Emma, Feinstein, Stuart C., Bowers, Michael T., Han, Songi
Publicado no J Phys Chem B (2015)

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport

Por Kanaan, Nicholas M., Morfini, Gerardo, Pigino, Gustavo, LaPointe, Nichole E., Andreadis, Athena, Song, Yuyu, Leitman, Ellen, Binder, Lester I., Brady, Scott T.
Publicado em 2011

Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants

Por Do, Thanh D., LaPointe, Nichole E., Sangwan, Smriti, Teplow, David B., Feinstein, Stuart C., Sawaya, Michael R., Eisenberg, David S., Bowers, Michael T.
Publicado em 2014

Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose on Amyloid β(25–35) Assembly

Por de Almeida, Natália E. C., Do, Thanh D., Tro, Michael, LaPointe, Nichole E., Feinstein, Stuart C., Shea, Joan-Emma, Bowers, Michael T.
Publicado no ACS Chem Neurosci (2015)

1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation

Por de Almeida, Natália E. C., Do, Thanh D., LaPointe, Nichole E., Tro, Michael, Feinstein, Stuart C., Shea, Joan-Emma, Bowers, Michael T.
Publicado no Int J Mass Spectrom (2016)

A Novel MAPT Mutation, G55R, in a Frontotemporal Dementia Patient Leads to Altered Tau Function

Por Iyer, Abhinaya, LaPointe, Nichole E., Zielke, Krzysztof, Berdynski, Mariusz, Guzman, Elmer, Barczak, Anna, Chodakowska-Żebrowska, Małgorzata, Barcikowska, Maria, Feinstein, Stuart, Żekanowski, Cezary
Publicado em 2013

Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

Por Ganguly, Pritam, Do, Thanh D., Larini, Luca, LaPointe, Nichole E., Sercel, Alexander J., Shade, Madeleine F., Feinstein, Stuart C., Bowers, Michael T., Shea, Joan-Emma
Publicado no J Phys Chem B (2015)

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

Por Kanaan, Nicholas M., Morfini, Gerardo A., LaPointe, Nichole E., Pigino, Gustavo F., Patterson, Kristina R., Song, Yuyu, Andreadis, Athena, Fu, Yifan, Brady, Scott T., Binder, Lester I.
Publicado em 2011

Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels

Por Do, Thanh D., LaPointe, Nichole E., Nelson, Rebecca, Krotee, Pascal, Hayden, Eric Y., Ulrich, Brittany, Quan, Sarah, Feinstein, Stuart C., Teplow, David B., Eisenberg, David, Shea, Joan-Emma, Bowers, Michael T.
Publicado no J Am Chem Soc (2016)

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

Por Gamblin, T. Chris, Chen, Feng, Zambrano, Angara, Abraha, Aida, Lagalwar, Sarita, Guillozet, Angela L., Lu, Meiling, Fu, Yifan, Garcia-Sierra, Francisco, LaPointe, Nichole, Miller, Richard, Berry, Robert W., Binder, Lester I., Cryns, Vincent L.
Publicado em 2003

Oligomerization of the Microtubule Associated Protein Tau is Mediated by its N-Terminal Sequences: Implications for Normal and Pathological Tau Action

Por Feinstein, H. Eric, Benbow, Sarah J., LaPointe, Nichole E., Patel, Nirav, Ramachandran, Srinivasan, Do, Thanh D., Gaylord, Michelle R., Huskey, Noelle E., Dressler, Nicolette, Korff, Megan, Quon, Brady, Cantrell, Kristi Lazar, Bowers, Michael T., Lal, Ratnesh, Feinstein, Stuart C.
Publicado no J Neurochem (2016)

Axonal Transport Defects in Neurodegenerative Diseases

Por Morfini, Gerardo A., Burns, Matthew, Binder, Lester I., Kanaan, Nicholas M., LaPointe, Nichole, Bosco, Daryl A., Brown, Robert H., Brown, Hannah, Tiwari, Ashutosh, Hayward, Lawrence, Edgar, Julia, Nave, Klaus-Armin, Garberrn, James, Atagi, Yuka, Song, Yuyu, Pigino, Gustavo, Brady, Scott T.
Publicado em 2009