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Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport

Alzheimer’s disease (AD) and other tauopathies are characterized by fibrillar inclusions composed of the microtubule-associated protein, tau. Recently, we demonstrated that the N-terminus of tau (aa 2–18) in filamentous aggregates or N-terminal tau isoforms activates a signaling cascade involving pr...

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Bibliografiske detaljer
Main Authors: Kanaan, Nicholas M., Morfini, Gerardo, Pigino, Gustavo, LaPointe, Nichole E., Andreadis, Athena, Song, Yuyu, Leitman, Ellen, Binder, Lester I., Brady, Scott T.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272324/
https://ncbi.nlm.nih.gov/pubmed/21794954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.06.006
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