The Amino Terminus of Tau Inhibits Kinesin-Dependent Axonal Transport: Implications for Filament Toxicity

The neuropathology of Alzheimer's disease (AD) and other tauopathies is characterized by filamentous deposits of the microtubule-associated protein tau, but the relationship between tau polymerization and neurotoxicity is unknown. Here, we examined effects of filamentous tau on fast axonal tran...

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Detalhes bibliográficos
Main Authors: LaPointe, Nichole E., Morfini, Gerardo, Pigino, Gustavo, Gaisina, Irina N., Kozikowski, Alan P., Binder, Lester I., Brady, Scott T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739042/
https://ncbi.nlm.nih.gov/pubmed/18798283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.21850
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