Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious, painful and dose-limiting side effect of cancer drugs that target microtubules. The mechanisms underlying the neuronal damage are unknown, but may include disruption of fast axonal transport, an essential microtubule-based process that...

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Bibliographic Details
Main Authors: LaPointe, Nichole E., Morfini, Gerardo, Brady, Scott T., Feinstein, Stuart C., Wilson, Leslie, Jordan, Mary Ann
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169189/
https://ncbi.nlm.nih.gov/pubmed/23711742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2013.05.008
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