Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. While axonal transport dysfunction is thought to represent a primary pathogenic factor in AD and other neurodegenerative...

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Autores principales: Kanaan, Nicholas M., Morfini, Gerardo A., LaPointe, Nichole E., Pigino, Gustavo F., Patterson, Kristina R., Song, Yuyu, Andreadis, Athena, Fu, Yifan, Brady, Scott T., Binder, Lester I.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2011
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391724/
https://ncbi.nlm.nih.gov/pubmed/21734277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0560-11.2011
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