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Pseudophosphorylation of Tau at S422 Enhances SDS-Stable Dimer Formation and Impairs Both Anterograde and Retrograde Fast Axonal Transport
In Alzheimer's disease (AD), tau undergoes numerous modifications, including increased phosphorylation at serine-422 (pS422). In the human brain, pS422 tau protein is found in prodromal AD, correlates well with cognitive decline and neuropil thread pathology, and appears associated with increas...
Shranjeno v:
| izdano v: | Exp Neurol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4992631/ https://ncbi.nlm.nih.gov/pubmed/27373205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.06.030 |
| Oznake: |
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