Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease

Although tau is the primary constituent of neurofibrillary tangles (NFTs), evidence suggests that its toxic moiety is oligomeric in Alzheimer disease (AD). In this regard, tau oligomers correlate more strongly with neuronal loss than NFTs and exhibit neurotoxicity in preclinical AD models. Here, we...

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Veröffentlicht in:J Neuropathol Exp Neurol
Hauptverfasser: Tiernan, Chelsea T, Mufson, Elliott J, Kanaan, Nicholas M, Counts, Scott E
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251641/
https://ncbi.nlm.nih.gov/pubmed/29378005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlx120
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