Factors That Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants

[Image: see text] Five different mutants of [Leu-5] Enkephalin YGGFL peptide have been investigated for fibril formation propensities. The early oligomer structures have been probed with a combination of ion-mobility mass spectrometry and computational modeling. The two peptides YVIFL and YVVFL form...

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Detalhes bibliográficos
Main Authors: Do, Thanh D., LaPointe, Nichole E., Sangwan, Smriti, Teplow, David B., Feinstein, Stuart C., Sawaya, Michael R., Eisenberg, David S., Bowers, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084844/
https://ncbi.nlm.nih.gov/pubmed/24915112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp502473s
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