Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels

In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer’s disease (AD), it is essential to determine the structures of toxic amyloid oligomers. However, for the amyloid β-protein peptide (Aβ), thought to be the seminal neuropathogenetic agent in AD, its fast...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Do, Thanh D., LaPointe, Nichole E., Nelson, Rebecca, Krotee, Pascal, Hayden, Eric Y., Ulrich, Brittany, Quan, Sarah, Feinstein, Stuart C., Teplow, David B., Eisenberg, David, Shea, Joan-Emma, Bowers, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741107/
https://ncbi.nlm.nih.gov/pubmed/26700445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b09536
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