Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels

In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer’s disease (AD), it is essential to determine the structures of toxic amyloid oligomers. However, for the amyloid β-protein peptide (Aβ), thought to be the seminal neuropathogenetic agent in AD, its fast...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Do, Thanh D., LaPointe, Nichole E., Nelson, Rebecca, Krotee, Pascal, Hayden, Eric Y., Ulrich, Brittany, Quan, Sarah, Feinstein, Stuart C., Teplow, David B., Eisenberg, David, Shea, Joan-Emma, Bowers, Michael T.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741107/
https://ncbi.nlm.nih.gov/pubmed/26700445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b09536
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