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Amyloid β-Protein C-terminal Fragments: Formation of Cylindrins and β-barrels

In order to evaluate potential therapeutic targets for treatment of amyloidoses such as Alzheimer’s disease (AD), it is essential to determine the structures of toxic amyloid oligomers. However, for the amyloid β-protein peptide (Aβ), thought to be the seminal neuropathogenetic agent in AD, its fast...

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Dades bibliogràfiques
Publicat a:J Am Chem Soc
Autors principals: Do, Thanh D., LaPointe, Nichole E., Nelson, Rebecca, Krotee, Pascal, Hayden, Eric Y., Ulrich, Brittany, Quan, Sarah, Feinstein, Stuart C., Teplow, David B., Eisenberg, David, Shea, Joan-Emma, Bowers, Michael T.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741107/
https://ncbi.nlm.nih.gov/pubmed/26700445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b09536
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