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1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation
The early oligomerization of amyloid β-protein (Aβ) is a crucial step in the etiology of Alzheimer’s disease (AD), in which soluble and highly neurotoxic oligomers are produced and accumulated inside neurons. In search of therapeutic solutions for AD treatment and prevention, potent inhibitors that...
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| Publicado no: | Int J Mass Spectrom |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644501/ https://ncbi.nlm.nih.gov/pubmed/29056865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2016.09.018 |
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