A Novel Small Molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose Mimics the Antiplatelet Actions of Insulin

BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport. Insulin has been shown to bind to its receptors on platelets and inhibit platelet activati...

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Detalhes bibliográficos
Main Authors: Perveen, Rehana, Funk, Kevin, Thuma, Jean, Wulf Ridge, Shelli, Cao, Yanyan, Akkerman, Jan Willem N., Chen, Xiaozhuo, Akbar, Huzoor
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206812/
https://ncbi.nlm.nih.gov/pubmed/22073153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026238
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