Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Tekijä Hédou, Damien, Godeau, Julien, Loaëc, Nadège, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Julkaisussa Molecules (2016)

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

Tekijä Hédou, Damien, Dubouilh-Benard, Carole, Loaëc, Nadège, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Julkaisussa Molecules (2016)

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

Tekijä Meine, Rosanna, Becker, Walter, Falke, Hannes, Preu, Lutz, Loaëc, Nadège, Meijer, Laurent, Kunick, Conrad
Julkaisussa Molecules (2018)

Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives

Tekijä Loidreau, Yvonnick, Dubouilh-Benard, Carole, Nourrisson, Marie-Renée, Loaëc, Nadège, Meijer, Laurent, Besson, Thierry, Marchand, Pascal
Julkaisussa Pharmaceuticals (Basel) (2020)

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Tekijä Walter, Anne, Chaikuad, Apirat, Helmer, Renate, Loaëc, Nadège, Preu, Lutz, Ott, Ingo, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad
Julkaisussa PLoS One (2018)

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

Tekijä Lechner, Christian, Flaßhoff, Maren, Falke, Hannes, Preu, Lutz, Loaëc, Nadége, Meijer, Laurent, Knapp, Stefan, Chaikuad, Apirat, Kunick, Conrad
Julkaisussa Molecules (2019)

Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

Tekijä He, Fei, Mai, Linh H., Longeon, Arlette, Copp, Brent R., Loaëc, Nadège, Bescond, Amandine, Meijer, Laurent, Bourguet-Kondracki, Marie-Lise
Julkaisussa Mar Drugs (2015)

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

Tekijä Foucourt, Alicia, Hédou, Damien, Dubouilh-Benard, Carole, Désiré, Laurent, Casagrande, Anne-Sophie, Leblond, Bertrand, Loäec, Nadège, Meijer, Laurent, Besson, Thierry
Julkaisussa Molecules (2014)

Sneaking Out for Happy Hour: Yeast-Based Approaches to Explore and Modulate Immune Response and Immune Evasion

Tekijä Angrand, Gaëlle, Quillévéré, Alicia, Loaëc, Nadège, Daskalogianni, Chrysoula, Granzhan, Anton, Teulade-Fichou, Marie-Paule, Fahraeus, Robin, Prado Martins, Rodrigo, Blondel, Marc
Julkaisussa Genes (Basel) (2019)

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

Tekijä Bettayeb, Karima, Baunbæk, Dianne, Delehouze, Claire, Loaëc, Nadège, Hole, Alison J., Baumli, Sonja, Endicott, Jane A., Douc-Rasy, Setha, Bénard, Jean, Oumata, Nassima, Galons, Hervé, Meijer, Laurent
Julkaistu 2010

10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A

Tekijä Falke, Hannes, Chaikuad, Apirat, Becker, Anja, Loaëc, Nadège, Lozach, Olivier, Abu Jhaisha, Samira, Becker, Walter, Jones, Peter G., Preu, Lutz, Baumann, Knut, Knapp, Stefan, Meijer, Laurent, Kunick, Conrad
Julkaisussa J Med Chem (2015)

Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis

Tekijä Jarry, Marie, Lecointre, Céline, Malleval, Céline, Desrues, Laurence, Schouft, Marie-Thérèse, Lejoncour, Vadim, Liger, François, Lyvinec, Gildas, Joseph, Benoît, Loaëc, Nadège, Meijer, Laurent, Honnorat, Jérôme, Gandolfo, Pierrick, Castel, Hélène
Julkaistu 2014

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Tekijä Nguyen, Thu Lan, Duchon, Arnaud, Manousopoulou, Antigoni, Loaëc, Nadège, Villiers, Benoît, Pani, Guillaume, Karatas, Meltem, Mechling, Anna E., Harsan, Laura-Adela, Limanton, Emmanuelle, Bazureau, Jean-Pierre, Carreaux, François, Garbis, Spiros D., Meijer, Laurent, Herault, Yann
Julkaisussa Dis Model Mech (2018)

CDK/CK1 inhibitors roscovitine and CR8 down-regulate amplified MYCN in neuroblastoma cells

Tekijä DELEHOUZE, Claire, GODL, Klaus, LOAEC, Nadège, BRUYERE, Céline, DESBAN, Nathalie, OUMATA, Nassima, GALONS, Hervé, ROUMELIOTIS, Theodoros I., GIANNOPOULOU, Eugenia G., GRENET, Jose, TWITCHELL, Devin, LAHTI, Jill, MOUCHET, Nicolas, GALIBERT, Marie-Dominique, GARBIS, Spiros D., MEIJER, Laurent
Julkaistu 2013

A new mouse model of ARX dup24 recapitulates the patients’ behavioral and fine motor alterations

Tekijä Dubos, Aline, Meziane, Hamid, Iacono, Giovanni, Curie, Aurore, Riet, Fabrice, Martin, Christelle, Loaëc, Nadège, Birling, Marie-Christine, Selloum, Mohammed, Normand, Elisabeth, Pavlovic, Guillaume, Sorg, Tania, Stunnenberg, Henk G, Chelly, Jamel, Humeau, Yann, Friocourt, Gaëlle, Hérault, Yann
Julkaisussa Hum Mol Genet (2018)

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Tekijä Loaëc, Nadège, Attanasio, Eletta, Villiers, Benoît, Durieu, Emilie, Tahtouh, Tania, Cam, Morgane, Davis, Rohan A., Alencar, Aline, Roué, Mélanie, Bourguet-Kondracki, Marie-Lise, Proksch, Peter, Limanton, Emmanuelle, Guiheneuf, Solène, Carreaux, François, Bazureau, Jean-Pierre, Klautau, Michelle, Meijer, Laurent
Julkaisussa Mar Drugs (2017)

TRPC6 channel translocation into phagosomal membrane augments phagosomal function

Tekijä Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.
Julkaisussa Proc Natl Acad Sci U S A (2015)

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Tekijä Meijer, Laurent, Nelson, Deborah J., Riazanski, Vladimir, Gabdoulkhakova, Aida G., Hery-Arnaud, Geneviève, Le Berre, Rozenn, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Nowak, Emmanuel, Gueganton, Laetitia, Dorothée, Guillaume, Prochazkova, Michaela, Hall, Bradford, Kulkarni, Ashok B., Gray, Robert D., Rossi, Adriano G., Witko-Sarsat, Véronique, Norez, Caroline, Becq, Frédéric, Ravel, Denis, Mottier, Dominique, Rault, Gilles
Julkaisussa J Innate Immun (2016)