CDK/CK1 inhibitors roscovitine and CR8 down-regulate amplified MYCN in neuroblastoma cells

To understand the mechanisms of action of (R)-roscovitine and (S)-CR8, two related pharmacological inhibitors of cyclin-dependent kinases (CDKs), we applied a variety of ‘-omics’ techniques to the human neuroblastoma SH-SY5Y and IMR32 cell lines: [1] kinase interaction assays, [2] affinity competiti...

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Main Authors: DELEHOUZE, Claire, GODL, Klaus, LOAEC, Nadège, BRUYERE, Céline, DESBAN, Nathalie, OUMATA, Nassima, GALONS, Hervé, ROUMELIOTIS, Theodoros I., GIANNOPOULOU, Eugenia G., GRENET, Jose, TWITCHELL, Devin, LAHTI, Jill, MOUCHET, Nicolas, GALIBERT, Marie-Dominique, GARBIS, Spiros D., MEIJER, Laurent
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4087096/
https://ncbi.nlm.nih.gov/pubmed/24317512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.513
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