Recent Advances in Transition-Metal-Free Late-Stage C-H and N-H Arylation of Heteroarenes Using Diaryliodonium Salts

por Besson, Thierry, Fruit, Corinne
Publicado en Pharmaceuticals (Basel) (2021)

Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-a][1,3,5]triazines

por Elie, Jonathan, Fruit, Corinne, Besson, Thierry
Publicado en Molecules (2021)

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

por Dallemagne, Patrick, Rochais, Christophe, Marchand, Pascal, Besson, Thierry
Publicado en Pharmaceuticals (Basel) (2019)

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

por Hédou, Damien, Godeau, Julien, Loaëc, Nadège, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Publicado en Molecules (2016)

Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation

por Hédou, Damien, Dubouilh-Benard, Carole, Loaëc, Nadège, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Publicado en Molecules (2016)

Microwave-Assisted Synthesis of Potential Bioactive Benzo-, Pyrido- or Pyrazino-thieno[3,2-d]pyrimidin-4-amine Analogs of MPC-6827

por Loidreau, Yvonnick, Nourrisson, Marie-Renée, Fruit, Corinne, Corbière, Cécile, Marchand, Pascal, Besson, Thierry
Publicado en Pharmaceuticals (Basel) (2020)

Demonstration of Green Solvent Performance on O,S,N-Heterocycles Synthesis: Metal-Free Click Chemistry and Buchwald—Hartwig Coupling

por Campos, Joana F., Cailler, Manon, Claudel, Remi, Prot, Benjamin, Besson, Thierry, Berteina-Raboin, Sabine
Publicado en Molecules (2021)

Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives

por Loidreau, Yvonnick, Dubouilh-Benard, Carole, Nourrisson, Marie-Renée, Loaëc, Nadège, Meijer, Laurent, Besson, Thierry, Marchand, Pascal
Publicado en Pharmaceuticals (Basel) (2020)

Synthesis of 2-Mercapto-(2-Oxoindolin-3-Ylidene)Acetonitriles from 3-(4-Chloro-5H-1,2,3-Dithiazol-5-Ylidene)Indolin-2-ones

por Letribot, Boris, Delatouche, Régis, Rouillard, Hervé, Bonnet, Antoine, Chérouvrier, Jean-René, Domon, Lisianne, Besson, Thierry, Thiéry, Valérie
Publicado en Molecules (2018)

Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A

por Fruit, Corinne, Couly, Florence, Bhansali, Rahul, Rammohan, Malini, Lindberg, Mattias F., Crispino, John D., Meijer, Laurent, Besson, Thierry
Publicado en Pharmaceuticals (Basel) (2019)

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I

por Foucourt, Alicia, Hédou, Damien, Dubouilh-Benard, Carole, Désiré, Laurent, Casagrande, Anne-Sophie, Leblond, Bertrand, Loäec, Nadège, Meijer, Laurent, Besson, Thierry
Publicado en Molecules (2014)

Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part II

por Foucourt, Alicia, Hédou, Damien, Dubouilh-Benard, Carole, Girard, Angélique, Taverne, Thierry, Casagrande, Anne-Sophie, Désiré, Laurent, Leblond, Bertrand, Besson, Thierry
Publicado en Molecules (2014)

Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole

por Guillon, Rémi, Pagniez, Fabrice, Picot, Carine, Hédou, Damien, Tonnerre, Alain, Chosson, Elizabeth, Duflos, Muriel, Besson, Thierry, Logé, Cédric, Le Pape, Patrice
Publicado 2013

Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

por Couly, Florence, Harari, Marine, Dubouilh-Benard, Carole, Bailly, Laetitia, Petit, Emilie, Diharce, Julien, Bonnet, Pascal, Meijer, Laurent, Fruit, Corinne, Besson, Thierry
Publicado en Molecules (2018)

DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

por Thompson, Benjamin J., Bhansali, Rahul, Diebold, Lauren, Cook, Daniel E., Stolzenburg, Lindsay, Casagrande, Anne-Sophie, Besson, Thierry, Leblond, Bertrand, Désiré, Laurent, Malinge, Sébastien, Crispino, John D.
Publicado en J Exp Med (2015)

DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3

por Bhansali, Rahul S., Rammohan, Malini, Lee, Paul, Laurent, Anouchka P., Wen, Qiang, Suraneni, Praveen, Yip, Bon Ham, Tsai, Yi-Chien, Jenni, Silvia, Bornhauser, Beat, Siret, Aurélie, Fruit, Corinne, Pacheco-Benichou, Alexandra, Harris, Ethan, Besson, Thierry, Thompson, Benjamin J., Goo, Young Ah, Hijiya, Nobuko, Vilenchik, Maria, Izraeli, Shai, Bourquin, Jean-Pierre, Malinge, Sébastien, Crispino, John D.
Publicado en J Clin Invest (2021)