Nucleoside Sensing

Tekijä Fokkens, Michael, Klärner, Frank-Gerrit, Schrader, Thomas
Julkaistu 2006

Molecular Tweezers for Lysine and Arginine – Powerful Inhibitors of Pathologic Protein Aggregation

Tekijä Schrader, Thomas, Bitan, Gal, Klärner, Frank-Gerrit
Julkaisussa Chem Commun (Camb) (2016)

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

Tekijä Hadrovic, Inesa, Rebmann, Philipp, Klärner, Frank-Gerrit, Bitan, Gal, Schrader, Thomas
Julkaisussa Front Chem (2019)

Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity

Tekijä Attar, Aida, Chan, Wai-Ting Coco, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Julkaistu 2014

Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03

Tekijä Zheng, Xueyun, Liu, Deyu, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Bowers, Michael T.
Julkaisussa J Phys Chem B (2015)

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

Tekijä Xu, Na, Bitan, Gal, Schrader, Thomas, Klärner, Frank‐Gerrit, Osinska, Hanna, Robbins, Jeffrey
Julkaisussa J Am Heart Assoc (2017)

Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01

Tekijä Sinha, Sharmistha, Du, Zhenming, Maiti, Panchanan, Klärner, Frank-Gerrit, Schrader, Thomas, Wang, Chunyu, Bitan, Gal
Julkaistu 2012

Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins

Tekijä Malik, Ravinder, Di, Jing, Nair, Gayatri, Attar, Aida, Taylor, Karen, Teng, Edmond, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Julkaisussa Methods Mol Biol (2018)

Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency

Tekijä Mason, Ashley J., Hurst, Ian, Malik, Ravinder, Siddique, Ibrar, Solomonov, Inna, Sagi, Irit, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Julkaisussa ACS Chem Neurosci (2020)

Molecular Tweezers Targeting Transthyretin Amyloidosis

Tekijä Ferreira, Nelson, Pereira-Henriques, Alda, Attar, Aida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Gales, Luís, Saraiva, Maria João, Almeida, Maria Rosário
Julkaistu 2014

Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer

Tekijä Acharya, Srabasti, Safaie, Brian M., Wongkongkathep, Piriya, Ivanova, Magdalena I., Attar, Aida, Klärner, Frank-Gerrit, Schrader, Thomas, Loo, Joseph A., Bitan, Gal, Lapidus, Lisa J.
Julkaistu 2014

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator

Tekijä Nshanian, Michael, Lantz, Carter, Wongkongkathep, Piriya, Schrader, Thomas, Klärner, Frank-Gerrit, Blümke, Anika, Despres, Clément, Ehrmann, Michael, Smet-Nocca, Caroline, Bitan, Gal, Loo, Joseph A.
Julkaisussa J Am Soc Mass Spectrom (2018)

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS

Tekijä Malik, Ravinder, Meng, Helen, Wongkongkathep, Piriya, Corrales, Christian I., Sepanj, Niki, Atlasi, Ryan S., Klärner, Frank-Gerrit, Schrader, Thomas, Spencer, Melissa J., Loo, Joseph A., Wiedau, Martina, Bitan, Gal
Julkaisussa J Biol Chem (2019)

Reducing synuclein accumulation improves neuronal survival after spinal cord injury

Tekijä Fogerson, Stephanie M., van Brummen, Alexandra J., Busch, David J., Allen, Scott R., Roychaudhuri, Robin, Banks, Susan M. L., Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal, Morgan, Jennifer R.
Julkaisussa Exp Neurol (2016)

Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos

Tekijä Lulla, Aaron, Barnhill, Lisa, Bitan, Gal, Ivanova, Magdalena I., Nguyen, Binh, O’Donnell, Kelley, Stahl, Mark C., Yamashiro, Chase, Klärner, Frank-Gerrit, Schrader, Thomas, Sagasti, Alvaro, Bronstein, Jeff M.
Julkaisussa Environ Health Perspect (2016)

Erratum to: A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity In Vitro and In Vivo

Tekijä Prabhudesai, Shubhangi, Sinha, Sharmistha, Attar, Aida, Kotagiri, Aswani, Fitzmaurice, Arthur G., Lakshmanan, Rajeswari, Ivanova, Magdalena I., Loo, Joseph A., Klärner, Frank-Gerrit, Schrader, Thomas, Stahl, Mark, Bitan, Gal, Bronstein, Jeff M.
Julkaistu 2012

A Novel “Molecular Tweezer” Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

Tekijä Prabhudesai, Shubhangi, Sinha, Sharmistha, Attar, Aida, Kotagiri, Aswani, Fitzmaurice, Arthur G., Lakshmanan, Ravi, Ivanova, Magdalena I., Loo, Joseph A., Klärner, Frank-Gerrit, Schrader, Thomas, Stahl, Mark, Bitan, Gal, Bronstein, Jeff M.
Julkaistu 2012

The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

Tekijä Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Julkaisussa Alzheimers Res Ther (2021)

Correction to: The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice

Tekijä Di, Jing, Siddique, Ibrar, Li, Zizheng, Malki, Ghattas, Hornung, Simon, Dutta, Suman, Hurst, Ian, Ishaaya, Ella, Wang, Austin, Tu, Sally, Boghos, Ani, Ericsson, Ida, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Julkaisussa Alzheimers Res Ther (2021)

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

Tekijä Monaco, Antonio, Maffia, Veronica, Sorrentino, Nicolina Cristina, Sambri, Irene, Ezhova, Yulia, Giuliano, Teresa, Cacace, Vincenzo, Nusco, Edoardo, De Risi, Maria, De Leonibus, Elvira, Schrader, Thomas, Klärner, Frank-Gerrit, Bitan, Gal, Fraldi, Alessandro
Julkaisussa Mol Ther (2020)